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Other studies have shown that curcumin attenuated cisplatin-induced nephrotoxicity and enhanced its anticancer activity in SD rats, demonstrating its potential role in breast cancer chemotherapy, and cumulative treatment augmented peroxisome proliferator-activated receptor- (PPAR-) expression while lessening BDNF expression in mammary tumors [130]
The GPX6 gene is located on chromosome 6p22.1 near the GPX5 gene and is composed of 5 exons that encode a 221 amino acid precursor protein
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