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Graphical Abstract The effects of GLP-1 agonists on weight loss in patients with inflammatory bowel disease were examined
Because peptides are delicate chains of amino acids, poor manufacturing processes can easily denature the compound, rendering it useless or, worse, harmful
Cotadutide, but not liraglutide improved hepatic parameters and metabolic dysfunction-associated steatohepatitis (MASH) with similar weight loss with 200 g cotadutide compared to 1.8 mg liraglutide and greater with 300 g cotadutide versus 1.8 mg liraglutide [47]
Adverse events across doses Adverse events reported in 5% of participants through 36 weeks Select Important Safety Information: Most common adverse reactions - Incidence reported in 5% of Trulicity-treated patients in trials were nausea, diarrhea, vomiting, abdominal pain, decreased appetite, dyspepsia, and fatigue
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