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Mollan, MBChB, FRCOphth, professor and neuro-ophthalmology consultant at the University of Birmingham, United Kingdom, wrote an invited commentary on the study in the same issue of JAMA Ophthalmology

The skin attributes improved at 12 weeks (as assessed by blind expert graders) for elasticity, wrinkles, and evenness in different body areas (face, hands, neck, etc.) compared with placebo measurements

When Zepbound causes quick changes in metabolism, the resulting shifts in blood flow may be too much for already vulnerable optic nerve blood vessels to handle

These mechanisms may interact at the ovary and endometrium, with downstream implications for oocyte competence, endometrial receptivity, and pregnancy outcomes