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2.2.2 Pyroptosis Activation of the NLRP3 inflammasome is a critical trigger of pyroptosis, leading to gasdermin-mediated membrane pore formation and excessive release of pro-inflammatory cytokines such as IL-1 and IL-18

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And in the STEP 3 trial, participants who received semaglutide 2.4 mg plus intensive behavioral therapy lost an average of 16.0% of their bodyweight (as compared to 5.7% in the placebo group)

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Michael Tahery after years of symptoms and multiple unsuccessful treatments