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63 , e12413 (2017)
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Exposing cerebral mitochondria to THC was reported to induce a ten-fold increase in free radical leak and increased H 2 O 2 production [40], while in epithelial cells, THC upregulated inflammation-related genes and downregulated antioxidant-related genes [34]
We synthesized putative 1,2-dicarbonyl prodrugs of MMF (compounds 1ac ) covering three distinct chemotypes (1,2-diketones, -ketoamides and -ketoesters
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