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Histamine binds to receptors on small blood vessels, making vessel walls more permeable (which allows fluid to leak and form the raised wheal) and dilating the vessels (which creates the surrounding redness)
& Ueki, I
MarquetLHausswirthCMolleOHawleyJBurkeLTiollierEet al
An open label, single site, 12 month, phase II, randomised controlled trial evaluating the safety and efficacy of Exendin-4 (exenatide) in the treatment of patients with moderate severity Parkinsons disease [abstract]
And also, it improves blood and lymphatic circulation
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