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Patients should be counseled about the risk of dehydration and potential acute kidney injury with severe gastrointestinal symptoms, and the need to temporarily hold medication and seek care if severe vomiting or diarrhea occurs

They can also assess whether medication adjustment, additional supportive therapies, or referral to specialists (such as a dietitian nutritionist or endocrinologist) would be beneficial

It is especially useful for men with circulation problems

Brydges CR, Bhattacharyya S, Dehkordi SM, Milaneschi Y, Penninx B, Jansen R, et al

People who are unable to absorb vitamin B12 from their diet or through their digestive system

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