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Moreover, as discussed, neither of these polymorphisms has a significant impact on in vitro susceptibility to PIB.[18] In support of these data, per the US Food and Drug Administration and European Medicines Agency product use labels, GT3-infected patients with compensated cirrhosis and/or prior treatment experience do not require viral resistance testing prior to treatment with G/P.[20] Altogether, the efficacy results from this study demonstrate that G/P is an all-oral DAA regimen with high cure rates that does not require RBV coadministration in HCV GT3-infected patients, regardless of other traditional negative predictors of response such as prior treatment experience or compensated cirrhosis