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25, 26 Owing to spatial compartmentalization, reaction kinetics and physiological functions of low ROS concentrations, the scavenging of ROS by cellular enzyme systems (for example, superoxide dismutase, catalase) is impaired

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So when it comes to estrogen hormone replacement therapy, that is helping restore the insulin sensitizing effects of estrogen, we also know that estrogen HRT can improve lipid profiles and it can blunt the visceral fat accumulation that we typically see in menopause