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Additionally, there are indirect factors influencing TJs, such as matrix metalloproteinases (MMPs), NO, ROS, Rho-associated protein kinase (ROCK), and NF-B signaling pathways [120,121,122,123,124]

These statements have not been evaluated by the FDA

The research team conducted a retrospective cohort study using electronic health records from the University of Pennsylvania Health System, which includes both academic and community medical sites across Pennsylvania and New Jersey