GLP-1 and GIP are incretin hormones that have been shown to influence insulin secretion, appetite, and glycemic control, while GCG primarily stimulates lipolysis, increases energy expenditure, and promotes fatty acid oxidation
GHRH-analogue / GHS combinations produce a larger GH pulse than either compound alone in published studies this is why most research protocols use ipamorelin with sermorelin, CJC-1295, or modified GRF(1-29) rather than as a monotherapy
doi:10.1016/j.bmc.2008.10.006 41
Studies suggest it may interact with hormone-related receptors, potentially affecting glucose utilization, appetite-related signals, and energy expenditure in controlled environments
doi: 10.3389/fimmu.2022.1089987 137 ZouJReddivariLShiZLiSWangYBretinAet al