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Variation applications Based on the risk of the proposed change and the approval requirement, variation applications are classified into three types: Major variation 1 (MAV-1) application Minor variation 1 (MIV-1) application Minor variation 2 (MIV-2) application The variation application must be submitted with the applicable evaluation route via SHARE

Fourth, a number of patients withdrew from the study but no causal association can be determined

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Vitamin C can react when paired with certain ingredients, and some forms of the antioxidant can be unstable