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Adverse events leading to discontinuation were reported by fewer than 6% of participants in both trials

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Moreover, beyond the loss of exendin-4-induced responses, we also find a significant effect of SPHKAP downregulation in mitochondrial morphology and other parameters under vehicle conditions, suggesting additional effects of this AKAP in -cells

Treat cause * Control diabetes * Control hypertension (ACE inhibitors preferred if proteinuria) 2