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This study demonstrates that cerebellar GABAergic plasticity is dependent on the identity of the presynaptic interneuron
Post-Exertional Malaise (PEM) and Severe Fatigue: By protecting mitochondrial membranes from lipid peroxidation and supporting efficient ATP production, glutathione helps restore cellular energy reserves, potentially reducing the severity and duration of exertion-induced crashes
Natural ways to support glutathione include sleep, exercise, sulfur-rich foods (broccoli, garlic, onions), vitamin C, selenium, and precursors like NAC and glycine
Larger multicenter trials with longer follow-up, standardized endpoints, and predictive biomarkers are needed to identify responder subgroups and establish evidence-based recommendations
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