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(3) Sikiric P, Udovicic M, Barisic, I et al
Some emerging research has explored potential connections between GLP-1 signalling and intestinal inflammation
De Leonardis V et al
Preclinical studies in accelerated mouse models of diet-induced steatohepatitis have demonstrated that retatrutide improves steatohepatitis through mechanisms involving enhanced hepatic fat oxidation, reduced lipogenesis, decreased inflammation, and attenuation of fibrosis markers, supporting the rationale for clinical development in MASH [33]
After millions of Rx, registry and real world data show no signal, yet the warning persists and dissuades many from a useful Rx #T2D gut.bmj.com/content/early/ Liraglutide, the first long acting GLP-1RA was approved 12 years ago with a black box warning for MTC based on rodent data
