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These improvements appeared as early as 4 weeks

Ann Diag Pathol 8:207212 Dammann O, Hagel C, Allers B, Grubel G, Schulte FJ (1995) Malignant melanotic neuroectodermal tumor of infancy

They are generally not recommended for people with a personal or family history of medullary thyroid carcinoma or MEN 2 (multiple endocrine neoplasia type 2)