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Critical Care Pharmacotherapy, second edition
25 Patients diagnosed with vitamin B 12 deficiency whose history and physical examination do not suggest an obvious dietary or malabsorptive etiology should be tested for pernicious anemia with anti-intrinsic factor antibodies (positive predictive value = 95%), particularly if other autoimmune disorders are present
Check the Certificate of Analysis (COA) for: Identity confirmation (MS data matching expected molecular weight) HPLC purity (greater than 98% is recommended for reliable research work) Fill weight (the actual mass of lyophilized peptide in the vial, which may differ slightly from the nominal amount) Expiration or retest date Using the fill weight from the COA rather than assuming the labeled amount ensures your concentration calculations are accurate
P., Mulligan, K., Schambelan, M., Murphy, E
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