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Unlike the combinatorial therapy of G-protein-coupled receptor-based peptide dual agonists, such as GLP-1/glucagon, these peptidyl nuclear hormone conjugates require additional consideration for differential pharmacodynamics where time action for clearance of each activity is inherently dissimilar
Therefore, we performed a scenario analysis in which we assumed that everyone who started an SGLT2i or GLP-1 RA would have initiated a different glucose-lowering medication at the same time, and thus the cost of SGLT2is and GLP-1 RAs was reduced by the mean cost of all other glucose-lowering medications ($288
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Largest trial reported increased risk and persistence of CIPN with prophylactic use
