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The growing popularity of GLP-1 receptor agonists, especially semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound), both of which are FDA-approved for type 2 diabetes and/or obesity and, has been accompanied by considerable social media attention and discussion, from which thorough analyses of user-generated data have emerged highlighting reductions in alcohol-seeking motivation, decreased drinking behavior, and altered subjective responses to alcohol (Arillotta et al
)
Treatment of pre-existing obesity: animals with genetic mutations (ob/ob or db/db mice) causing obesity or high-fat diet-induced obesity at baseline
Microglia also use alternative receptors such as TREM2 (Triggering Receptor Expressed on Myeloid cells 2), which regulates the transition to the DAM phenotype [126, 447]
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