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In the first study, the Authors observed that GLP-1 levels were similar in PCOS and controls in the early phase of the 75-g oral glucose tolerance test (OGTT) until 60 min, but that GLP-1 levels were significantly lower after 180 min, suggesting that women with PCOS might have reduced GLP-1 secretion in the late postprandial phase [45]

'But, because they weren't hungry, some of that behaviour and interaction with the owner changed - the suppression of the appetite was something that was seen as a negative by the owners.' If GLP-1 mimics are going to be successful this time around, Dr German says owners will likely need counselling and support to ensure they understand any potential behaviour changes

Second, the data from AMPLITUDE-O improved the certainty about the effect of GLP-1 receptor agonists on hospital admission for heart failure, with the updated meta-analysis showing an 11% reduction

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What mechanisms in the central nervous system (CNS) and satiety hormone signaling contribute to the challenges of maintaining weight loss after initial success, and how might GLP-1 receptor agonists address these issues