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Cagrilintide is a long-acting amylin analogue with dual amylin and calcitonin receptor activity, whereas semaglutide is a once-weekly GLP-1 receptor agonist with robust anti-hyperglycemic and appetite-suppressing effects

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All three medications reduce triglycerides, but retatrutide produces the largest reductions, likely because of the glucagon-driven increase in fat oxidation

In AD, tau becomes hyperphosphorylated and dissociates from microtubules, resulting in the formation of intracellular neurofibrillary tangles (Pavani and Tiwari, 2024)