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Notably, Russian researchers have conducted follow-up examinations as part of a 15-year study on elderly human volunteers who had received up to six courses of epithalamin treatment, observing no adverse events attributable to the peptide
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Figure 7: Changes in the levels of A) IL-1-beta, B) TNF-alpha, and C) IL-10 in each of the four different experimental groups included in the first part of the study
It primarily manifests as motor symptoms due to the degeneration of dopamine-producing neurons in the substantia nigra pars compacta (SNpc), including tremors, bradykinesia (slowness of movement), muscle rigidity, and impaired coordination