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Las potenciales explicaciones incluyen diferencias en el tipo de pacientes incluidos, la adherencia al tratamiento del estudio, el tamao muestral, la duracin de la exposicin al frmaco y la activacin del receptor GLP1 con una mayor reduccin de HbA1c con anlogos basados en GLP1 humano de accin ms prolongada que con algunos anlogos de exendina 4 de accin corta

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