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For example, the SELECT trial reported that semaglutide reduced the risk of MACE by 20% (Hazard Ratio (HR) 0.80, 95% confidence interval (CI) 0.720.90) in people with obesity but without diabetes, although several secondary outcomes did not reach statistical significance under hierarchical testing procedures

However, CagriSema and retatrutide (both in late-stage development) more closely match tirzepatide weight loss results , with CagriSema achieving 20% and retatrutide achieving up to 29% body weight reduction in trials

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GLP-1 drugs can cause gastrointestinal side-effects such as nausea, vomiting, diarrhoea and constipation