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GLP-1 to Enable Reductions in Methadone Dose Size Does semaglutide or tirzepatide (given at first visit and ongoing) facilitate a reduction in dose or sustainable termination of methadone for patients currently on MMT for OUD
The medicine works by helping to activate the melanocortin 4 receptors in the brain
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The Swedish investigators were appropriately measured in their interpretation, noting residual confounding and the observational designs inherent limits, but the signal is consistent enough to prompt serious mechanistic questions
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