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Those on placebo lost an average of only 0.6% of their body weight
Oncotarget 8 , 8402884038 (2017)
Shrink the Bulging of Subcutaneous Fat Pockets to Reduce Cellulite To decrease the subcutaneous fat pockets, they need to be locally directed Losing weight often does not help in decreasing the appearance of cellulite
Sullivan, L
You can verify this in reputable drug references that describe tirzepatide specifically as an injection under the skin (Mayo Clinic) and in FDA labeling for products like Zepbound, which is explicitly injection, for subcutaneous use (FDA label PDF)
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