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In catecholamine biosynthesis of brain and adrenal provides reducing equivalents for dopamine -hydroxylase in the conversion of dopamine to nor-epinephrine, and protects the brain against glutamate mediated excitotoxicity by decreasing the available amount of extracellular glutamate.It can interfere with glutamatergic, dopaminergic, cholinergic and GABAergic transmission and related behaviors

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Advances in Bioscience and Biotechnology, 15 , 573-589

Additionally, glutathione levels naturally decrease with age, partly due to a decline in the rate of synthesis

Endocr Rev (2012) 33(6):9811030