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The hydrophilic nature and large molecular weight of these molecules prevent passive diffusion across enterocytes, and paracellular transport is restricted by TJ complexes, which typically exclude molecules larger than 1 nm or 600 Da (Shen et al., 2011
Toxicology 149:4350 Thomas C, Mackey MM, Diaz AA, Cox DP (2009) Hydroxyl radical is produced via the Fenton reaction in submitochondrial particles under oxidative stress: implications for diseases associated with iron accumulation
10 Interestingly, ALC may help alleviate depression in older adults, potentially by restoring phosphomonoester levels in the prefrontal cortex to normal
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