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Reduced liver weight or reduced steatosis-associated features in a diet-induced model should not be interpreted as proof of broad hepatic safety unless supported by appropriate histological assessment, serum chemistry, inflammatory markers, and study-duration-specific monitoring

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( 1 subtype activates the NADPH oxydase complex, thus providing a major source of ROS ( 1 receptor results in the stimulation of the NF-kB signal transduction pathway facilitating the synthesis of chemokine, cytokines, and adhesion molecules, all important in the migration of inflammatory cells into regions of tissue injury ( If AngII activation of the AT 1 receptor subtype results in facilitation of the NADPH oxidase complex and formation of free radicals, then blockade of the AT 1 receptor should serve a protective function