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Similarly, another retrospective study looking at people living with diabetes and obesity reported a 37% reduction in dementia risk over a 7-year follow-up period 2
These preclinical insights have been validated in large-scale clinical trials.The FLOW trial (n = 3,533) showed that once-weekly subcutaneous administration of semaglutide (1.0 mg) significantly reduced the risk of a renal composite endpointincluding 50% decline in eGFR, renal failure, or cardiovascular deathby 24% in patients with T2DM and chronic kidney disease (CKD) (HR = 0.76, 95% CI: 0.660.88
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ACS Infect Dis 2020;6:155862 25
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