Stability is influenced by peptide concentration, preservative formulation, vial material, and headspace sterility
Patients with advanced type 2 diabetes on insulin Both oral and injection semaglutide were effective in reducing body weight in patients with advanced, uncontrolled type 2 diabetes already on insulin therapy
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Hypoglycemia (low blood sugar) can occur, especially when Zepbound is used in combination with insulin or sulfonylureas, though the risk is lower when used as monotherapy due to its glucose-dependent mechanism of action
Taking breaks is generally not recommended because restarting requires gradual dose escalation, and intermittent use may reduce effectiveness or increase side effects