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tirzepatide lowered HbA 1c by 2.01 to 2.30 percentage points versus 1.86 for semaglutide, meeting non-inferiority and superiority, with greater weight loss as well
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However, past pancreatitis is not a contraindication for these agents, and contrary to the previous warning, recent studies have not shown an increased pancreatic risk associated with GLP-1 RAs, leading to ongoing revisions in treatment guidelines
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