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Which matters for: Joint health Falls risk Long-term function Aging well Researchers are actively working on next-generation therapies designed to target fat mass while preserving lean mass , reflecting growing recognition that body composition, not just weight, matters for long-term health and function: read more In Canada, an estimated 1 in 7 adults (more than 4 million people) are living with osteoarthritis , and that number is expected to rise significantly over the next decade as the population ages and rates of metabolic disease increase
1a) 52,57,58,59 , and truncation of a single C-terminal amino acid residue (L585) weakens FcRn binding affinity and, consequently, reduces its in vivo plasma half-life 60,65
This finding aligns with others observations of ER swelling and increased expression of ER stress markers in a mouse model of AP
Health plans and others will need to make choices not only around their efficacy, but around whether theyre affordable to provide to our members