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IGF1 is a primary mediator of GH activity and directly influences muscle hypertrophy, protein synthesis, and nutrient partitioning (Yakar et al., Endocrinology )

Due to the complexity of the kidney, as an organ containing specialized structures and multiple cell types, it becomes quite difficult to find a reliable model system to study the effects or toxicity of drugs and their metabolites on this organ

Interaction with Epithalon leads to the activation of several genes, including the gene MMP2 found also in the skin that regulates this protein, as well as the activation of fibroblasts producing and maintaining MMP2

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