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Both medications share similar side effectsmainly nausea, vomiting, and diarrheathough retatrutide shows slightly higher rates of gastrointestinal issues in early studies
10.1038/s41575-020-00385-2 Nat
Cytoprotection Originally studied for gut protection, it appears to help maintain cellular integrity under stress
For thyroid C-cell tumors specifically, the FDA requires a boxed warningthe agency's strongest safety warningfor several products including semaglutide (Ozempic, Wegovy, Rybelsus), liraglutide (Victoza, Saxenda), dulaglutide (Trulicity), exenatide extended-release (Bydureon BCise), and tirzepatide (Mounjaro, Zepbound)
And even as GLP-1 injectables have become more common, the idea of giving yourself an injection can still feel intimidating or overwhelmingespecially at first
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