TRIM37 and TRIM28 act with AP2 to remodel chromatin and repress somatic gene programs To further explore the molecular mechanisms underlying the repression of gene expression by the TRIM37TRIM28 complex, we first explored the relationship between chromatin accessibility and gene transcription following Trim37 inactivation using RNA-seq and ATAC-seq analyzes of PGCs at E9.25 (Supplementary information, Fig
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Using this approach, several potential targets have been identified, including PRKACA, NCOA2, and PPARA, which play crucial roles in regulating neuroendocrine function, metabolism, and neuro-immunity [246]