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What we have is an enormous amount of anecdotal reporting, mostly from athletes and biohackers who've used it for injury recovery, combined with animal data that's mechanistically compelling
B12 has very low toxicity and increased levels are not thought to be dangerous
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Pharmacokinetic characterisation is comparatively thin, but distribution and elimination have been profiled in rats and dogs in a 2023 pharmacokinetic study (PMC9794587), which is useful context because most claims about systemic healing rest on animal exposure data rather than validated human pharmacology
KPV (Lys-Pro-Val) Evidence of TB-500s benefits is limited to animal and preclinical research, with only a few well-designed human studies showing that the peptide could safely improve wound healing and promote sports recovery
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