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Rossing P, Agarwal R, Anker SD, Filippatos G, Pitt B, Ruilope LM, Fonseca V, Umpierrez GE, Caramori ML, Joseph A, et al

Why Symptom-Based Pain Relief Often Fails Long Term Across medication classes, a consistent pattern emerges: pain is temporarily quieted while the systems required for healing are progressively weakened

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Receptor expression patterns, metabolic pathways, and healing kinetics can vary across species, potentially limiting direct translation of animal findings