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These processes contribute to impaired microcirculation and elevated cardiovascular risk in CKD

How the Three Pathways Work Together What makes the design work is that the three receptor pathways complement each other: GLP-1 reduces energy intake (you eat less) GIP optimizes how that energy is used (better insulin sensitivity, favorable fat distribution) Glucagon increases energy expenditure (you burn more calories at rest and mobilize stored fat) The net effect: you eat less, your body uses energy more efficiently, and you burn more calories at rest

Certain conditions, allergies, and interactions make it unsafe for some individuals

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Schauer, P