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Contributions of the microbial hydrogen economy to colonic homeostasis
By eliminating senescent cells, FOXO4-DRI treatment appears to create a more permissive environment for endogenous stem cell activation and tissue renewal, contributing to improvements in organ function and physical capacity
Meanwhile, long-term use also disrupts intestinal microbiota (bacteria and fungi), risks multidrug-resistant fungi, and carries hepatotoxic or even fatal side effects 169,170
However, the results may depend on genetic factors and more research is needed
Europace 20 , 12521258 (2018)
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