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In general, peptides are well-tolerated by most dogs when used appropriately
In contrast, substitution to an amidated proline instead of an amidated tyrosine in the C-terminus of rAmy is well tolerated, resulting in enhanced affinity and activity at both the CTR and AMYRs, but, in some cases, reduced selectivity between these receptors 18
Some of these issues could be alleviated with robust human-based research, followed by FDA approval if warranted
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