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The origins and specifications of the mice used in this study are detailed in the Supplemental Methods
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Tier 2: BMI of 30 or Higher with a Qualifying Condition If your BMI is at least 30 but below 35, you can still qualify if you have been diagnosed with one or more of the following conditions: heart failure with preserved ejection fraction, uncontrolled hypertension (defined as systolic blood pressure above 140 mm Hg or diastolic above 90 mm Hg despite concurrent treatment with two antihypertensive medications), or chronic kidney disease at stage 3a or above
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