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The -subunit (Kv1.1) exhibits the oxidoreductase activity and contains the NADPH-binding site, which is thought to be the sensor of intracellular redox potential that in turn regulates the channel [95]
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PubMed, Field, David T., et al
Tsaousidou E, Paeger L, Belgardt BF, Pal M, Wunderlich CM, Brnneke H, Collienne U, Hampel B, Wunderlich FT, Schmidt-Supprian M, Kloppenburg P, Brning JC (2014) Distinct roles for JNK and IKK activation in Agouti-related peptide neurons in the development of obesity and insulin resistance
Higher doses may actually accelerate any desensitization that occurs
