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A 2024 phase 2 trial published in Nature Medicine enrolled 98 adults with confirmed obesity and fatty liver, treating them with retatrutide once weekly for 48 weeks
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The UNC School of Medicine lab of Zoe McElligott, PhD, and colleagues found that the animal tranquilizer xylazine activates opioid receptors in the brain, suggesting a reason why the treatment naloxone triggers a more severe withdrawal response when given to individuals on fentanyl/xylazine and suffering from respiratory depression
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