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Semaglutide works by mimicking the action of the naturally occurring hormone GLP-1, which stimulates insulin secretion in a glucose-dependent manner, suppresses glucagon release, and slows gastric emptying

The choice between injection and oral depends on individual priorities and response patterns

Timing patterns from pooled data The STEP trials pooled data reveals several important timing patterns: The incidence of new-onset nausea was highest during the dose escalation period (weeks 1 to 20) and decreased substantially once participants reached maintenance dosing

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