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Activation of the janus kinase/STAT (signal transducer and activator of transcription) signal transduction pathway by interleukin-6-type cytokines promotes osteoblast differentiation

However, considering the baseline characteristics of the population enrolled in the SUSTAIN and PIONEER programs, BMI in our population was still higher in OW semaglutide group and lower in oral semaglutide group [25, 26]

The two routes use fundamentally different dosing logic, and mixing them produces incorrect protocols

They serve different purposes: You dont need to choose one over the other