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Also, dosage adjustments may be necessary in patients with significantly reduced kidney function
Participants then underwent a four-week washout period and switched to the other treatment for four additional weeks
In rat pinealocytes (the melatonin-producing cells of the pineal gland), Epitalon was shown to upregulate both AANAT (arylalkylamine N-acetyltransferase, the rate-limiting enzyme in melatonin production) and pCREB (a transcription factor involved in melatonin gene expression)
This adaptive capacity also contributes to resistance against a wide range of anticancer therapies, many of which further exacerbate ER stress
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