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The change in MBV can be considered substantial, given that even small increases in tissue MBV markedly improve oxygen supply when tissue total blood flow is limited, such as in the presence of coronary atherosclerosis

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The fact that the findings were similar across CFS and hypothyroidism points to the possibility that low peripheral serotonin may be a common theme across some disorders that include fatigue

Author contributions AS: conceptualization, formal analysis, investigation, methodology, resources, supervision, validation, visualization, and writingoriginal draft

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