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This aligns with previous studies demonstrating that mitochondrial dysfunction exacerbates tau pathology by promoting tau hyperphosphorylation and aggregation, which lead to the neurofibrillary tangles characteristic of AD [39]

And while from the outside it may seem like its not the worst thing to happen, it can set the stage for some pretty nasty health issues, including type 2 diabetes, obesity, metabolic syndrome, cardiovascular disease, NAFLD, PCOS, and more 12

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