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Diabetologia 2002;45:11111119 EXENATIDE AND LIRAGLUTIDE Effectively reduce HbA1c Preserve beta cell function Promote weight loss Correct known pathophysiologic defects in T2DM Do not cause hypoglycemia Have an excellent safety profile Rad 03/20/00 Triplitt & DeFronzo, Expert Rev Endo Metab 1:329-41, 2006 TIME COURSE OF EFFECT OF EXENATIDE ON HbA1c Time (weeks) 0 20 40 60 80 156 0.5 Placebo Baseline HbA1C=8.3% 0 Exenatide- 10 g bid DeFronzo et al, Diabetes Care 28:1092-1100, 2005 D HbA1c (%) Klonoff et al, Curr Med Res Opin 24:275-285, 2008 -1.0 Exenatide- 10 g bid -2.0 Open-Label Extension Placebo-Controlled Trials EFFECT OF EXENATIDE VERSUS GLARGINE INSULIN ON INSULIN SECRETION IN T2DM Subjects: 59 T2DM

La parcial permeabilidad de la barrera hematoenceflica en estructuras circunventriculares y ncleo arcuato, junto a la potencial participacin GLP-1R dependiente de los tanicitos, permite el acceso de LIRA y SEMA a estructuras esenciales en el control de la ingesta

The copper stays local, the bioavailability jumps, and you sidestep the systemic question

Liraglutide suppresses postprandial triglyceride and apolipoprotein B48 elevations after a fat-rich meal in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled, cross-over trial

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